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Monoclonal gammopathy of undetermined significance (MGUS, ''unknown'' or ''uncertain'' may be substituted for ''undetermined''), formerly benign monoclonal gammopathy, is a condition in which a paraprotein is found in the blood during standard laboratory tests. It resembles multiple myeloma and similar diseases, but the levels of antibody are lower, the number of plasma cells (white blood cells that secrete antibodies) in the bone marrow is lower, it has no symptoms or problems, and no treatment is indicated. However, multiple myeloma develops at the rate of about 1.5% a year, so doctors recommend monitoring it yearly. In rare cases, it may also be related with a slowly progressive symmetric distal sensorimotor neuropathy.〔Kahn, S. N., Riches, P. G., & Kohn, J. (1980). Paraproteinaemia in neurological disease: incidence, associations, and classification of monoclonal immunoglobulins. Journal of clinical pathology, 33(7), 617-621. ()〕 ==Diagnosis== MGUS is a common, age-related medical condition characterized by an accumulation of bone marrow plasma cells derived from a single abnormal clone. Patients may be diagnosed with MGUS if they fulfill the following four criteria: #A monoclonal paraprotein band lesser than 30 g/L (< 3g/dL); #Plasma cells less than 10% on bone marrow examination; #No evidence of bone lesions, anemia, hypercalcemia, or renal insufficiency related to the paraprotein, and #No evidence of another B-cell proliferative disorder. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Monoclonal gammopathy of undetermined significance」の詳細全文を読む スポンサード リンク
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